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The overall survival demonstrated at the higher doses in our clinical trial with only two cycles of treatment is clinically meaningful in comparison to published outcomes in this patient population.

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Pharmacologic treatment for episodic migraine prevention in adults” (Silberstein et al, 2012a) and “NSAIDs and other complementary treatments for episodic migraine prevention in adults” (Holland et al, 2012) had no recommendation for intravenous methylprednisolone or other steroids, or for nalbuphine (Nubain) or other opioid agonist-antagonists for migraine treatment.

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Only 4 original articles of various study designs were found studying complementary and alternative medicine (CAM) therapies for SSc patients.

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II dose-ranging study to assess single intravenous doses of palonosetron for the prevention of highly emetogenic chemotherapy-induced nausea and vomiting.

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The following treatment comparisons were statistically significant using both the CIs and PrIs: all agents (except for palonosetron plus dexamethasone and granisetron plus droperidol intravenous (IV)) versus placebo, ondansetron plus droperidol IV versus ondansetron, granisetron plus dexamethasone versus ondansetron, ondansetron plus dexamethasone versus dolasetron, ondansetron plus droperidol IV versus dolasetron, granisetron plus dexamethasone versus dolasetron, palonosetron plus dexamethasone versus ondansetron plus dexamethasone, palonosetron plus dexamethasone versus ondansetron plus droperidol IV, and palonosetron plus dexamethasone versus granisetron plus dexamethasone (Fig.

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Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG, Consolidated Standards of Reporting Trials G (2010) CONSORT 2010 Explanation and Elaboration: Updated guidelines for reporting parallel group randomised trials.

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